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MITEC
Media Intima Thickness Evaluation of Candesartan
Ongoing trial
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Author(s) |
Valensi P, Baguet J-P, Asmar R, Nisse-Durgeat S, Mallion J-M |
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Title(s) |
Effect of candesartan cilexetil on carotid intima-media thickness in hypertensive type 2 diabetic patients. MITEC study: design and baseline characteristics |
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Reference(s) |
Br J Diabetes Vasc Dis 2007;7:18–24 |
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Disease |
Diabetes mellitus, carotid artery stenosis |
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Purpose |
To assess the effect of candesartan vs amlodipine on carotid artery intima-media thickness in hypertensive patients with type 2 diabetes |
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Study design |
Randomised, double-blind, parallel-group |
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Follow-up |
Aim 3 years |
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Patients |
209 (100 candesartan, 109 amlodipine), mean age 59.7 ± 8.5 years, with HbA1c ≤ 10%, SBP 140–180 mm Hg, DBP 90–109 mm Hg, fasting total cholesterol < 250 mg/dl, LDL < 160 mg/dl, triglycerides < 400 mg/dl and carotid artery intima-media thickness 0.6–1.2 mm |
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Treatment regimen |
Candesartan cilexetil, 8 mg/day, or amlodipine, 5 mg/day, increased to candesartan, 16 mg/day, or amlodipine, 10 mg/day after 4 weeks if SBP ≥ 130 mm Hg and/or DBP ≥ 85 mm Hg. Hydrochlorothiazide, 12.5 mg added after 2 months if BP targets not reached |
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Results |
Not yet available |
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