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ENOS
Efficacy of Nitric Oxide in Stroke
Ongoing trial
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Author(s) |
ENOS trial investigators |
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Title(s) |
Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122) |
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Reference(s) |
Int J Stroke 2006;1:245–9 |
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Disease |
Stroke |
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Purpose |
To test the safety and efficacy of transdermal glyceryl trinitrate, and of continuing or stopping temporarily prior antihypertensive medication, in patients with acute ischaemic or haemorrhagic stroke |
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Study design |
Randomised, single-blind, parallel-group, partial-factorial |
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Follow-up |
Aim 90 days |
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Patients |
Aim 5000 patients with acute ischaemic or haemorrhagic stroke, of whom it is assumed approximately 2500 will be taking antihypertensive therapy immediately before stroke |
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Treatment regimen |
Glyceryl trinitrate patch, 5 mg/day, or no patch, within 48 h of stroke onset and for 7 days, or until discharge if earlier |
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Concomitant therapy |
Patients taking pre-stroke antihypertensive therapy will be randomised to continue or stop this temporarily |
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Results |
Not yet available |
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