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TIME-CHF
Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure
Ongoing trial
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Author(s) |
Brunner-La Rocca HP, Buser PT, Schindler R, Bernheim A, Rickenbacher P, Pfisterer M
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Title(s) |
Management of elderly patients with congestive heart failure – design of the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF)
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Reference(s) |
Am J Heart 2006;151:949–55
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Disease |
Congestive heart failure |
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Purpose |
To compare the medical management of very old patients with congestive heart failure to that of younger patients and to compare an intensified approach vs a standard treatment |
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Study design |
Randomised, single-blind, 2 × 2 factorial |
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Follow-up |
Aim 18 months |
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Patients |
Aim 824 patients, aged 60–74 or ≥ 75 years, with symptomatic congestive heart failure, hospitalised within the past year and with elevated N-terminal brain natriuretic peptide |
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Treatment regimen |
Standard medical treatment, to reduce symptoms to NYHA class ≤ II, or intensified treatment, to additionally reduce N-terminal brain natriuretic peptide levels to below twice the upper limit of normal |
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Results |
Not yet available |
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