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J-ELAN
Effect of losartan and amlodipine on left ventricular diastolic function in patients with mild-to-moderate hypertension
Ongoing trial
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Author(s) |
J-ELAN investigators
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Title(s) |
Effect of losartan and amlodipine on left ventricular diastolic function in patients with mild-to-moderate hypertension (J-ELAN). Rationale and design
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Reference(s) |
Circ J 2006;70:124–8 |
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Disease |
Hypertension |
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Purpose |
To compare the effects of losartan with those of amlodipine on left ventricular diastolic function in hypertensive patients with left ventricular diastolic dysfunction without systolic dysfunction |
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Study design |
Randomised, open, blinded endpoint, parallel-group |
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Follow-up |
Aim 18 months |
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Patients |
Aim 300 patients, aged ≥ 20 years, with SBP 140–200 mm Hg, DBP 90–110 mm Hg, left ventricular hypertrophy and left ventricular ejection fraction ≥ 50% |
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Treatment regimen |
Losartan, 50 mg/day, titrated to 100 mg/day after 4 weeks, or amlodipine, 2.5 mg/day, titrated to 5 mg/day, to target blood pressure < 140/90 mm Hg |
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Results |
Not yet available |
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