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ACTFAST-2
Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration – 2
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Author(s) |
Farsang C, Athyros V, Gaw A |
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Title(s) |
A multicentre, open study to assess the effect of individualizing starting doses of atorvastatin according to baseline LDL-C levels on achieving cholesterol targets: the Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (ACTFAST-2) study |
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Reference(s) |
Curr Med Res Opin 2007;23:1945–56 |
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Disease |
Hypercholesterolaemia |
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Purpose |
To assess the efficacy of matching the starting dose of atorvastatin to baseline LDL cholesterol in the achievement of LDL-cholesterol target levels < 100 mg/dl within 12 weeks with the initial atorvastatin dose or one up-titration |
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Study design |
Open |
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Follow-up |
12 weeks |
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Patients |
600 patients (347 statin-free, 253 statin-treated), mean age 61.2 ± 9.8, with LDL cholesterol 100–220 mg/dl, triglycerides ≤ 600 mg/dl, a history of coronary heart disease (or equivalent, defined as diabetes, cerebrovascular disease or peripheral vascular disease) or estimated 1-year coronary heart disease risk > 20% |
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Treatment regimen |
Atorvastatin, 10, 20, 40 or 80 mg/day, according to LDL-cholesterol level and status of statin use at baseline, titrated to next highest dose, if required, except for those allocated to 80 mg |
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Results |
68.0% of patients (73.5% statin-free and 60.5% statin-treated) achieved LDL-cholesterol target |
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