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FINCAVAS
Finnish Cardiovascular Study
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Author(s) |
(a) Nieminen T, Lehtinen R, Viik J, Lehtimäki T, Niemelä K, Nikus K, Niemi M, Kallio J, Kööbi T, Turjanmaa V, Kähönen M
(b) Nieminen T, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Niemelä K, Turjanmaa V, Kaiser W, Huhtala H, Verrier RL, Huikuri H, Kähönen M
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Title(s) |
(a) The Finnish Cardiovascular Study (FINCAVAS): characterising patients with high risk of cardiovascular morbidity and mortality
(b) T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test
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Reference(s) |
(a) BMC Cardiovasc Disord 2006;6:9
(b) Eur Heart J 2007;28:2332–7
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Disease |
Cardiovascular disease |
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Purpose |
To construct a risk profile, using genetic, haemodynamic and ECG markers, of individuals at high risk of cardiovascular disease events and death |
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Study design |
Open, observational |
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Follow-up |
44 ± 7 months
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Patients |
1037 patients (673 men, 364 women), mean age 58 ± 13 years, scheduled for exercise stress test
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Results |
59 patients died during follow-up, 34 due to cardiovascular causes and 20 due to sudden cardiac death. After adjustments for gender, age, body mass index, smoking, use of beta-blockers, functional class, maximal heart rate during exercise, previous MI and other coronary risk factors, the relative risk of T-wave alternans ≥ 65 µV was 7.4 for sudden cardiac death (95% CI 2.8–19.4; p < 0.001), 6.0 for cardiovascular mortality (95% CI 2.8–12.8; p < 0.001) and 3.3 for all-cause mortality (95% CI 1.8–6.3; p = 0.001)
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Comments |
This study has been the basis for a number of publications. A selection of references:
Atrioventricular conduction and cardiovascular mortality
– Nieminen T et al, Heart Rhythm 2010;7:796–801
Detection of coronary artery disease in women
– Svart K et al, Int J Cardiol 2010;140:182–8
Exercise-test-related heart rate variability and mortality
– Leino J et al, Int J Cardiol 2009;6:1765–71
Heart rate variability in the detection of coronary artery disease
– Virtanen M et al, Physiol Meas 2007;28:1189–200
Prognostic value of haemodynamic parameters in exercise recovery
– Nieminen T et al, J Hum Hypertens 2008;22:537–43
Secondary prevention of coronary heart disease
– Michou SM et al, Clin Drug Investig 2007;27:673–81
T-wave alternans during exercise and post-exercise
– Minkkinen M et al, J Cardiovasc Electrophysiol 2009;20:408–15
– Slawnych MP et al, J Am Coll Cardiol 2009;53:1130–7
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