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CENTAURUS
Comparison of the Effects Noted in the ApoB/ApoA-I ratio Using Rosuvastatin and atorvastatin in patients with acute coronary Syndrome
Ongoing trial
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Author(s) |
(a) Lablanche J-M, Tardif J-C, Benkritly A
(b) Lablanche J-M, Danchin N, Farnier M, Tedgui A, Vicaut E, Alonso J, Crean P, Leone A, Morais J, Santini M, Licour M, Farah M, Tardif J-C |
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Title(s) |
(a) Effects of rosuvastatin and atorvastatin on the ApoB/ApoA-I ratio in patients with acute coronary syndrome: the CENTAURUS study
(b) Effects of rosuvastatin and atorvastatin on the apolipoprotein B/apolipoprotein A-1 ratio in patients with an acute coronary syndrome: The CENTAURUS trial design |
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Reference(s) |
(a) Atheroscler Suppl 2006;7:578
(b) Arch Cardiovasc Dis 2008;101:399–406 |
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Disease |
Acute coronary syndromes |
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Purpose |
To assess the effects of rosuvastatin and atorvastatin on apolipoproteins, lipids and inflammatory markers in patients with acute coronary syndromes |
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Study design |
Randomised, double-blind, parallel-group (double-dummy in the second period) |
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Follow-up |
3 months |
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Patients |
Aim 1075 patients, aged 18–75 years, with non-ST-elevation acute coronary syndrome receiving percutaneous coronary intervention. Time from onset of symptoms: ≤ 24 h |
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Treatment regimen |
Rosuvastatin, 20 mg/day, or placebo at admission, then rosuvastatin, 20 mg/day, or atorvastatin, 80 mg/day, at discharge |
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Results |
Not yet available |
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Comments |
This trial is part of the GALAXY Programme published in Expert Opin Pharmacother 2004;5:1187–200
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