(a) Feldman HI, Appel LJ, Chertow GM, Cifelli D, Cizman B, Daugirdas J, Fink JC, Franklin-Becker ED, Go AS, Hamm L, He J, Hostetter T, Hsu C-Y, Jamerson K, Joffe M, Kusek JW, Landis JR, Lash JP, Miller ER, Mohler ER III, Muntner P, Ojo AO, Rahman M, Townsend RR, Wright JT, and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
(b) Townsend RR, Anderson AH, Chen J, Gadebegku CA, Feldman HI, Fink JC, Go AS, Joffe M, Nessel LA, Ojo A, Rader DJ, Reilly MP, Teal V, Teff K, Wright JT, Xie D

(a) The Chronic Renal Insufficiency Cohort (CRIC) study. Design and methods
(b) Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study

(a) J Am Soc Nephrol 2003;14:S148–53
(b) Am J Nephrol 2011;33:477–84

Chronic renal failure

To examine risk factors for progression of chronic renal insufficiency and cardiovascular disease among patients with chronic renal insufficiency, and to develop predictive models to identify high-risk subgroups

Observational

5 years

3939 patients, mean age 58.2 years

The prevalence of metabolic syndrome was 65% and there was a significant association with prevalent cardiovascular disease. 87.5% of patients with diabetes mellitus and 44.3% without diabetes had metabolic syndrome. Hypertension was the most prevalent component and increased triglycerides > 150 mg/dl the least common. The model considering metabolic syndrome as a single interval-scaled variable was deemed the best fit

Data on the association between pulse wave analysis and carotid intima-media thickness among 367 patients enrolled at one CRIC study site have been published in Am J Hypertens 2009;22:1235–41