|
WACS
Women’s Antioxidant Cardiovascular Study
Ongoing trial
 |
Author(s) |
Bassuk SS, Albert CM, Cook NR, Zaharris E, MacFadyen JG, Danielson E, Van Denburgh M, Buring JE, Manson JE |
 |
Title(s) |
The Women’s Antioxidant Cardiovascular Study: design and baseline characteristics of participants |
|
Reference(s) |
J Womens Health 2004;13:99–117 |
|
Disease |
Cardiovascular disease |
|
Purpose |
To investigate whether supplementation with antioxidant vitamins and folic acid prevents cardiovascular events in women with pre-existing cardiovascular disease or with three or more cardiovascular risk factors |
|
Study design |
Randomised, double-blind, placebo-controlled, parallel-group, 2 x 2 x 2 x 2 factorial |
|
Follow-up |
Aim 9.6 years in the antioxidant arms, 7.4 years in the folic acid arm |
|
Patients |
8171 women, mean age 60.6 years, with pre-existing cardiovascular disease or ≥ 3 cardiovascular risk factors |
|
Treatment regimen |
Vitamin E (D-alpha-tocopherol acetate), 600 U every other day, and/or vitamin C (ascorbic acid), 500 mg/day, and/or beta-carotene, 50 mg every other day, and/or combination of folic acid, 2.5 mg/day, vitamin B6, 50 mg/day, and vitamin B12, 1 mg/day, or placebo |
|
Results |
Not yet available |
|
Comments |
In a WACS substudy of 5218 patients who reported their BP, SBP was found to be a strong independent predictor of secondary cardiovascular events. The study has been
published in Circulation 2004;109:1623–9 |
|
|
|
