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TROICA
Thrombolysis in Cardiac Arrest
Ongoing trial
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Author(s) |
Spöhr F, Arntz HR, Bluhmki E, Bode C, Carli P, Chamberlain D, Danays T, Poth J, Skamira C, Wenzel V, Böttiger BW |
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Title(s) |
International multicentre trial protocol to assess the efficacy and safety of tenecteplase during cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest: the Thrombolysis in Cardiac Arrest (TROICA) Study |
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Reference(s) |
Eur J Clin Invest 2005;35:315–23 |
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Disease |
Cardiac arrest |
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Purpose |
To assess the efficacy and safety of tenecteplase administered during life support in patients with cardiac arrest of presumed cardiac origin |
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Study design |
Randomised, double-blind, placebo-controlled |
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Follow-up |
Aim 30 days |
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Patients |
Aim 1000 patients, aged ≥ 18 years, with out-of-hospital cardiac arrest of presumed cardiac origin and either basic life support started within 10 min of onset and performed up to 10 min or advanced life support started within 10 min of onset |
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Treatment regimen |
Tenecteplase, 30–50 mg (depending on body weight) single-dose iv bolus, or placebo |
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Results |
Not yet available |
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