Friedrich MG, Dahlöf B, Sechtem U, Unger T, Knecht M, Dietz R

Telmisartan Effectiveness on Left ventricular MAss Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension – a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months – rationale and study design

J Renin Angiotensin Aldosterone Syst 2003;4:234–43

Hypertension, left ventricular hypertrophy

To compare the effect of telmisartan to that of metoprolol on left ventricular mass index in patients with hypertension and left ventricular hypertrophy

Randomised, double-blind, parallel-group

Aim 6.5 months

Aim 140 patients, aged 18–80 years, with mild to moderate hypertension and left ventricular hypertrophy documented by magnetic resonance imaging

Telmisartan, 40 mg/day for 2 weeks, then 80 mg/day for 5.5 months, then 40 mg/day for 2 weeks, or metoprolol, 47.5 mg/day for 2 weeks, then 95 mg/day for 5.5 months, then 47.5 mg/day for 2 weeks

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