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Look AHEAD
Action for Health in Diabetes
Ongoing trial
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Author(s) |
(a) Look AHEAD Research Group
(b) Ribisl PM, Lang W, Jaramillo SA, Jakicic JM, Stewart KJ, Bahnson J, Bright R, Curtis JF, Crow RS, Soberman JE |
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Title(s) |
(a) Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes
(b) Exercise capacity and cardiovascular/metabolic characteristics of overweight and obese individuals with type 2 diabetes |
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Reference(s) |
(a) Control Clin Trials 2003;24:610–28
(b) Diabetes Care 2007;30:2679–84 |
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Disease |
Diabetes mellitus |
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Purpose |
To compare the long-term effects of an intensive weight-loss programme on the time to incidence for major cardiovascular events in overweight and obese patients with type 2 diabetes |
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Study design |
Randomised, open |
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Follow-up |
Aim up to 11.5 years |
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Patients |
5145 patients, mean age 58.7 ± 6.8 years, with type 2 diabetes and mean body mass index 35.9 ± 5.9 kg/m2
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Treatment regimen |
Intensive lifestyle intervention designed to achieve and maintain weight loss through reduced caloric intake and increased physical activity, or diabetes support and education, for 4 years |
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Results |
Not yet available |
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Comments |
Data on the relationship among baseline characteristics and suboptimal control of glycaemia, BP and LDL cholesterol in the Look AHEAD population have been published in J Diabetes Complications 2008;22:1–9. Data on the relationship between erectile dysfunction, cardiovascular risk factors and cardiorespiratory fitness in the Look AHEAD population have been published in J Sex Med 2009;6:1414–22
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