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CASHMERE
Carotid Atorvastatin Study in Hyperlipidemic post-Menopausal women
Ongoing trial
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Author(s) |
Simon T, Boutouyrie P, Gompel A, Christin-Maitre S, Laurent S, Thuillez C, Zannad F, Bernaud C, Jaillon P |
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Title(s) |
Rationale, design and methods of the CASHMERE study |
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Reference(s) |
Fundam Clin Pharmacol 2004;18:131–8 |
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Disease |
Hypercholesterolaemia |
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Purpose |
To compare the effects of atorvastatin alone, hormone replacement therapy (HRT) alone, their combination or placebo on the progression of carotid intima-media thickness in postmenopausal women with mild hypercholesterolaemia |
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Study design |
Randomised, open (HRT), double-blind (atorvastatin), placebo-controlled, 2 x 2 factorial |
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Follow-up |
Aim 1 year |
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Patients |
Aim 800 women, aged ≤ 70 years, ≤ 10 years menopausal, with LDL cholesterol ≥ 130 and ≤ 190 mg/dl, and no history of cardiovascular disease |
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Treatment regimen |
Atorvastatin, 40 mg/day, or HRT (17-beta-oestradiol, 1 mg/day, plus cyclic dydrogesterone, 10 mg/day), or both, or placebo. After 28 days, the dose of atorvastatin was doubled, and the dose of oestradiol could be doubled at the discretion of the physician |
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Results |
Not yet available |
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