Author(s) |
AF-CHF Trial Investigators |
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Title(s) |
Rationale and design of a study assessing treatment strategies of atrial fibrillation in patients with heart failure: The Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial |
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Reference(s) |
Am Heart J 2002;144:597–607 |
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Disease |
Atrial fibrillation, heart failure |
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Purpose |
To compare the effects of a rhythm-control treatment strategy to a rate-control strategy on cardiovascular mortality in patients with atrial fibrillation and congestive heart failure |
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Study design |
Randomised, open |
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Follow-up |
Aim 2 years |
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Patients |
Aim 1450 patients, aged ≥ 18 years, with heart failure NYHA class II–IV and left ventricular ejection fraction ≤ 35%, or heart failure NYHA I and prior hospitalisation for congestive heart failure or left ventricular ejection fraction ≤ 25%, and one episode of atrial fibrillation ≥ 6 h within last 6 months or one episode ≥ 10 min within last 6 months and prior electrical cardioversion |
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Treatment regimen |
Rhythm control: antiarrhythmic drugs, nonpharmacological treatment and cardioversion as needed Rate control: beta-blockers, digoxin, or both, atrioventricular nodal ablation and pacemaker implantation as needed |
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Results |
Not yet available |
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