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KEEPS
Kronos Early Estrogen Prevention Study
Ongoing trial
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Author(s) |
Harman SM, Brinton EA, Cedars M, Lobo R, Manson JE, Merriam GR, Miller VM, Naftolin F, Santoro N |
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Title(s) |
KEEPS: The Kronos Early Estrogen Prevention Study |
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Reference(s) |
Climacteric 2005;8:312 |
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Disease |
Cardiovascular disease |
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Purpose |
To determine the effects of early initiation of hormone therapy on the prevention of cardiovascular disease in postmenopausal women |
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Study design |
Randomised, double-blind, placebo-controlled |
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Follow-up |
Aim 5 years |
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Patients |
Aim 720 women, aged 42−58 years, within 36 months of their final menstrual period |
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Treatment regimen |
Conjugated equine oestrogens, 0.45 mg/day, plus progesterone, 200 mg/day for 12 days each month, or transdermal oestradiol, 50 µg/week, plus progesterone, or placebo |
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Results |
Not yet available |
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