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COPE
Combination therapy of hypertension to Prevent cardiovascular Events
Ongoing trial
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Author(s) |
Ogihara T, Matsuzaki M, Matsuoka H, Shimamoto K, Shimada K, Rakugi H, Umemoto S, Kamiya A, Suzuki N, Kumagai H, Ohashi Y, Takishita S, Abe K, Saruta T |
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Title(s) |
The combination therapy of hypertension to prevent cardiovascular events (COPE) trial: rationale and design |
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Reference(s) |
Hypertens Res 2005;28:331–8 |
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Disease |
Hypertension |
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Purpose |
To compare the effects of benidipine in combination with angiotensin-receptor blockers, beta-blockers or thiazide diuretics on cardiovascular events and BP in patients with hypertension |
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Study design |
Randomised, open |
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Follow-up |
Aim 3 years |
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Patients |
Aim 3000 patients, aged 40–85 years, with BP ≥ 140/90 mm Hg |
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Treatment regimen |
Benidipine, 4–8 mg, plus angiotensin-receptor blocker, beta-blocker or thiazide diuretic |
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Results |
Not yet available |
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