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HOMED-BP
Hypertension Objective treatment based on Measurement by Electrical Devices of BP
Ongoing trial
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Author(s) |
(a) Fujiwara T, Nishimura T, Ohkuko T, Imai Y
(b) Saito S, Asayama K, Ohkubo T, Kikuya M, Metoki H, Obara T, Hashimoto J, Totsune K, Miura Y, Imai Y, and the HOMED-BP Study Group
(c) Hosohata K, Sato S, Asayama K, Ohkubo T, Kikuya M, Metoki H, Obara T, Kato T, Hashimoto J, Totsune K, Miura Y, Imai Y, and the HOMED-BP Study Group |
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Title(s) |
(a) Rationale and design of HOMED-BP study: Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure study
(b) The second progress report on the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study
(c) Progress report on the Hypertension Objective treatment based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study: status at February 2004 |
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Reference(s) |
(a) Blood Press Monit 2002;7:77–82
(b) Blood Press Monit 2004;9:243–7
(c) Clin Exp Hypertens 2007;29:69–81 |
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Disease |
Hypertension
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Purpose |
To determine an optimal target BP level, based on BP values self-measured at home and to determine the optimal antihypertensive medication for the Japanese hypertensive population
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Study design |
Randomised, controlled, 2 × 3 factorial
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Follow-up |
7 years
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Patients |
Aim 9000 patients, aged 40-78 years, with untreated essential hypertension and home BP ≥ 135/85 mm Hg
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Treatment regimen |
Regimens based on calcium antagonists or ACE inhibitors or angiotensin-receptor blockers for either more intensive BP control (SBP < 125 mm Hg, DBP < 80 mm Hg) or less intensive BP lowering (BP 125-134/80-84 mm Hg)
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Concomitant therapy |
Diuretics, alpha-blocker or beta-blocker plus any other antihypertensive drug, at the discretion of the physician
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Results |
Interim analysis evaluated BP-controlled conditions of 653 patients during the initial 6 months. Home BP decreased to 134 ± 12/82 ± 10 mm Hg with calcium antagonists, 136 ± 15/80 ± 10 mm Hg with ACE inhibitors and 134 ± 13/80 ± 9 mm Hg with angiotensin-receptor blockers. In the more-intensive group, home BP decreased to 134 ± 14/81 ± 10 mm Hg and, in the less-intensive group, to 135 ± 12/81 ± 9 m Hg. There were no significant differences between groups with regard to treatment regimens or different target BP levels. In 971 patients, followed up for 12 months in February 2004, BP decreased to 131 ± 11/80 ± 9 mm Hg with calcium antagonists, 134 ± 12/79 ± 9 mm Hg with ACE inhibitors and 132 ± 13/79 ± 8 mm Hg with angiotensin-receptor blockers. In the more-intensive group, BP decreased to 132 ± 13/80 ± 9 mm Hg and, in the less-intensive group, to 133 ± 12/79 ± 8 mm Hg. Final results not yet available |
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