Author(s) |
Bloomfield Rubins H, Robins SJ, Iwane MK et al
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Title(s) |
Rationale and design of the department of Veterans Affairs High-density lipoprotein cholesterol Intervention Trial (HIT) for secondary prevention of coronary artery disease in men with low high-density lipoprotein cholesterol and desirable low-density lipoprotein cholesterol
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Reference(s) |
Am J Cardiol 1993;71:45-52
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Disease |
Coronary artery disease
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Purpose |
To determine whether lipid-lowering therapy reduces the combined incidence of death due to coronary artery disease and nonfatal Ml in men with established coronary artery disease, low levels of HDL cholesterol and satisfactory levels of LDL cholesterol
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Study design |
Randomised, double-blind, placebo-controlled
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Follow-up |
5-7 years
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Patients |
2500 men, aged ≤ 73 years, with coronary artery disease, HDL cholesterol ≤ 40 mg/dl, LDL cholesterol ≤ 140 mg/dl and triglycerides ≤ 300 mg/dl
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Treatment regimen |
Gemfibrozil, 1200 mg once daily, or placebo
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Concomitant therapy |
Health counselling and the American Heart Association Step 1 diet
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Results |
Not yet available
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