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AIREX
AIRE Extension study
Author(s)
Hall AS, Murray GD, Ball SG
Title(s)
Follow-up study of patients randomly allocated ramipril or placebo for heart failure after myocardial infarction: AIRE Extension (AIREX) study
Reference(s)
Lancet 1997;349:1493-7
Disease
AMI with heart failure
Purpose
To assess the long-term (3 years after the end of AIRE) survival benefits of ramipril compared to placebo in the UK patients from the AIRE study
Study design
Retrospective, controlled
Follow-up
3 years
Patients
603 patients (302 initially on ramipril, 301 initially on placebo)
Treatment regimen
See treatment for the AIRE study
Results
Death from all causes had occurred in 117/301 previously placebo-treated patients and 83/302 previously ramipril-treated patients. This is a statistically significant relative risk reduction of 36%
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