Author(s) |
Galatro KM, Adams PC, Cohen M, McBride R, Blake H
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Title(s) |
Bleeding complications and INR control of combined warfarin and low-dose aspirin therapy in patients with unstable angina and non-Q-wave myocardial infarction
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Reference(s) |
J Thrombosis Thrombolysis 1998;5:249-55
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Disease |
Non-Q-wave MI and unstable angina pectoris
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Purpose |
To compare bleeding complications in patients with non-Q-wave MI and unstable angina receiving aspirin plus warfarin to those in patients receiving aspirin alone
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Study design |
Randomised
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Follow-up |
12 weeks
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Patients |
358 patients (214 had not previously taken aspirin, 144 had previously taken aspirin)
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Treatment regimen |
Patients previously treated with aspirin: aspirin, 75 mg/day, plus anticoagulants Patients not previously treated with aspirin: aspirin, 162,5 mg/day, with or without anticoagulants
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Concomitant therapy |
Nitrates, beta-blockers and calcium antagonists
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Results |
The rates of major bleeding complications not associated with CABG or PTCA and minor bleeding were low (2% and 2.8%, respectively), and did not differ significantly between treatment groups. Combination therapy with low-dose aspirin and anticoagulation led to an insignificant rise in the incidence of major and minor bleeding
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