Author(s) |
Parisi AF, Folland ED, Hartigan P
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Title(s) |
A comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease
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Reference(s) |
N Engl J Med 1992;326:10-6
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Disease |
Stable angina pectoris, coronary artery stenosis
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Purpose |
To study whether PTCA is better than medical treatment for coronary artery stenosis
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Study design |
Randomised
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Follow-up |
6 months
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Patients |
212 patients (107 drug therapy, 105 PTCA)
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Treatment regimen |
Oral isosorbide dinitrate with sublingual glyceryl trinitrate and/or beta-blockers and/or calcium antagonists. PTCA group: calcium antagonists before and during 1 month after PTCA, heparin at PTCA and glyceryl trinitrate during and 12 h after the procedure
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Concomitant therapy |
Aspirin, 325 mg/day
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Results |
Paired exercise tests were performed by 199 patients. Both groups showed an increase in total exercise duration: 0.5 min for the drug therapy group and 2.1 min for the PTCA group (p < 0.001). In the drug therapy group, the maximal heart rate-blood pressure product decreased 2800 units compared to an increase of 1800 units for the PTCA group (p < 0.0001). Angina was reduced by 15 attacks/month in the PTCA group and 7 attacks/month in the drug therapy group (p < 0.06). The quality of life score improved by 8.6 units in the PTCA group and by 2.4 units in the drug therapy group (p = 0.03)
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