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ASCEND-HF
Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure
Ongoing trial
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Author(s) |
Hernandez AF, O’Connor CM, Starling RC, Reist CJ, Armstrong PW, Dickstein K, Lorenz TJ, Gibler WB, Hasselblad V, Komajda M, Massie B, McMurray JJV, Nieminen M, Rouleau JL, Swedberg K, Califf RM |
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Title(s) |
Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial (ASCEND-HF) |
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Reference(s) |
Am Heart J 2009;157:271–7 |
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Disease |
Heart failure |
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Purpose |
To evaluate the efficacy and safety of nesiritide in addition to standard therapy in patients with acute decompensated heart failure |
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Study design |
Randomised, double-blind, placebo-controlled |
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Follow-up |
6 h, 24 h and 30 days |
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Patients |
Aim 7000 patients, aged ≥ 18 years, hospitalised for the management of decompensated heart failure |
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Treatment regimen |
Nesiritide, 2 µg/kg iv bolus followed by 0.010 µg/kg/min, or placebo |
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Concomitant therapy |
Standard therapy at the discretion of the physician |
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Results |
Not yet available |
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