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ICAP
Investigation on Colchicine for Acute Pericarditis
Ongoing trial
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Author(s) |
Imazio M, Cecchi E, Ierna S, Trinchero R |
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Title(s) |
Investigation on Colchicine for Acute Pericarditis: a multicenter randomized placebo-controlled trial evaluating the clinical benefits of colchicine as adjunct to conventional therapy in the treatment and prevention of pericarditis; study design amd rationale |
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Reference(s) |
J Cardiovasc Med 2007;8:613–7 |
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Disease |
Acute pericarditis |
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Purpose |
To evaluate the efficacy and safety of colchicine in the treatment of acute pericarditis and prevention of recurrent pericarditis |
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Study design |
Randomised, double-blind, placebo-controlled |
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Follow-up |
18 months |
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Patients |
Aim 240 patients, aged ≥ 18 years, with a first episode of acute pericarditis with idiopathic or viral aetiology, pericardial injury syndromes or other autoimmune aetiology, including connective tissue diseases |
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Treatment regimen |
Colchicine, 1–2 mg the first day, followed by 0.5–1 mg/day for 3 months, or placebo |
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Concomitant therapy |
ASA, 800 mg orally every 6–8 h for 7–10 days, with gradual tapering over 3–4 weeks |
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Results |
Not yet available |
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