|
MARIA
Melatonin Adjunct in the acute myocardial Infarction treated with Angioplasty
Ongoing trial
 |
Author(s) |
Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia-Gonzalez MJ, Kaski JC, Reiter RJ, Jimenez-Sosa A |
 |
Title(s) |
A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty. The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: Study design and rationale |
|
Reference(s) |
Contemp Clin Trials 2007;28:532–9 |
|
Disease |
AMI |
|
Purpose |
To test whether melatonin reduces infarct size and improves clinical outcome when given as an adjunct to reperfusion treatment in patients with AMI |
|
Study design |
Randomised, double-blind, placebo-controlled, parallel-group |
|
Follow-up |
Aim 3 months |
|
Patients |
Aim 272 patients (136 melatonin, 136 placebo), aged 18–75 years, experiencing continuous ischaemic symptoms for at least 20 min, with onset of symptoms of qualifying AMI within the past 6 h, expected to undergo primary angioplasty and acute ST-segment elevation |
|
Treatment regimen |
Melatonin, 11.61 mg iv, or placebo |
|
Results |
Not yet available |
|
|
|
